An unusual case of temporal lobe tuberculoma with co-existing fungal infection in a diabetic patient is reported. A 54-year-old male with uncontrolled Diabetes mellitus was treated with anti-tuberculosis drugs for six months for temporal lobe tuberculoma. Follow-up scans showed increase in the size of the lesion in-spite of good drug compliance. After complete excision of the lesion, the pus encountered was sent for microbiological investigations, which showed acid-fast bacilli and multi-polar budding yeast cells. So, the patient was treated with antituberculosis drugs and Itraconazole. Follow-up scans after six months showed good resolution. In conclusion, any tuberculoma, which does not respond to medical management alone, should be surgically excised and evaluated for any other co-existing infection.